And the input is already TimePoint2-TimePoint1? If so, then you will need two more contrasts: [1 0 0 ....] and [0 1 0 ....]. The first tells you if controls are thinning (blue) or thickening (red), the 2nd tells you if the training is doing the same. doug
On 10/25/2012 03:34 PM, Ryan wrote:
Doug, Yes, it's a longitudinal study since we MRI participants pre-training and post-training.
On Thu, Oct 25, 2012 at 2:37 PM, Douglas N Greve <greve@nmr.mgh.harvard.edu mailto:greve@nmr.mgh.harvard.edu> wrote:
I'm not sure I understand. Is this a longitudinal study? On 10/25/2012 01:26 PM, Ryan wrote: Doug, Also, how can I tell if it's thickening or thinning if red/blue corresponds to the group? Thanks for the help. ---------- Forwarded message ---------- From: *Douglas N Greve* <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>> Date: Thu, Oct 25, 2012 at 12:20 PM Subject: Re: Files To: Ryan <wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu>>> That contrast will compute training-controls. In the maps, red/yellow will mean training>controls, blue/cyan otherwise doug On 10/25/2012 12:47 AM, Ryan wrote: Doug, Here are the Xg.dat (where the first column is for controls and the second column is for training subjects) and mtx files, I didn't use the FSGD design. Please let me know if this is sufficient for you to answer my question, thank you very much. -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> Phone Number: 617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>> Fax: 617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail. -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> Phone Number: 617-724-2358 <tel:617-724-2358> Fax: 617-726-7422 <tel:617-726-7422> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html>-- -Ryan
Doug, Actually my input is not the difference map, but the separate time points (it's timepoint 2 weighted with -1 and timepoint 1 weighted with 1, described in the matrix file I sent you). So in order to determine whether there's thickening or thinning in the controls and training subjects, would I still need to use the additional contrasts [1 0 0 ....] and [0 1 0 ....]? Thank you.
On Thu, Oct 25, 2012 at 3:48 PM, Douglas N Greve greve@nmr.mgh.harvard.eduwrote:
And the input is already TimePoint2-TimePoint1? If so, then you will need two more contrasts: [1 0 0 ....] and [0 1 0 ....]. The first tells you if controls are thinning (blue) or thickening (red), the 2nd tells you if the training is doing the same. doug
On 10/25/2012 03:34 PM, Ryan wrote:
Doug, Yes, it's a longitudinal study since we MRI participants pre-training and post-training.
On Thu, Oct 25, 2012 at 2:37 PM, Douglas N Greve < greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.**edugreve@nmr.mgh.harvard.edu>> wrote:
I'm not sure I understand. Is this a longitudinal study? On 10/25/2012 01:26 PM, Ryan wrote: Doug, Also, how can I tell if it's thickening or thinning if red/blue corresponds to the group? Thanks for the help. ---------- Forwarded message ---------- From: *Douglas N Greve* <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>Date: Thu, Oct 25, 2012 at 12:20 PM Subject: Re: Files To: Ryan <wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu>>> That contrast will compute training-controls. In the maps, red/yellow will mean training>controls, blue/cyan otherwise doug On 10/25/2012 12:47 AM, Ryan wrote: Doug, Here are the Xg.dat (where the first column is for controls and the second column is for training subjects) and mtx files, I didn't use the FSGD design. Please let me know if this is sufficient for you to answer my question, thank you very much. -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.**edu<greve@nmr.mgh.harvard.edu><mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>>> Phone Number: 617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>> Fax: 617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>> Bugs: surfer.nmr.mgh.harvard.edu/**fswiki/BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.**harvard.edu/fswiki/**BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting><http://surfer.nmr.mgh.**harvard.edu/fswiki/**BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting>FileDrop: www.nmr.mgh.harvard.edu/**facility/filedrop/index.html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.**edu/facility/filedrop/index.**html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html><http://www.nmr.mgh.harvard.**edu/facility/filedrop/index.**html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html>The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/**complianceline<http://www.partners.org/complianceline>. If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail. -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.**edu<greve@nmr.mgh.harvard.edu>Phone Number: 617-724-2358 <tel:617-724-2358> Fax: 617-726-7422 <tel:617-726-7422> Bugs: surfer.nmr.mgh.harvard.edu/**fswiki/BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.**harvard.edu/fswiki/**BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting>FileDrop: www.nmr.mgh.harvard.edu/**facility/filedrop/index.html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.**edu/facility/filedrop/index.**html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html>-- -Ryan
-- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu Phone Number: 617-724-2358 Fax: 617-726-7422
Bugs: surfer.nmr.mgh.harvard.edu/**fswiki/BugReportinghttp://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting FileDrop: www.nmr.mgh.harvard.edu/**facility/filedrop/index.htmlhttp://www.nmr.mgh.harvard.edu/facility/filedrop/index.html
Hi Ryan, I'm a little lost here. Can you resend your X and contrast matrices and explain what each column is? doug
On 10/26/2012 03:45 PM, Ryan wrote:
Doug, Actually my input is not the difference map, but the separate time points (it's timepoint 2 weighted with -1 and timepoint 1 weighted with 1, described in the matrix file I sent you). So in order to determine whether there's thickening or thinning in the controls and training subjects, would I still need to use the additional contrasts [1 0 0 ....] and [0 1 0 ....]? Thank you.
On Thu, Oct 25, 2012 at 3:48 PM, Douglas N Greve <greve@nmr.mgh.harvard.edu mailto:greve@nmr.mgh.harvard.edu> wrote:
And the input is already TimePoint2-TimePoint1? If so, then you will need two more contrasts: [1 0 0 ....] and [0 1 0 ....]. The first tells you if controls are thinning (blue) or thickening (red), the 2nd tells you if the training is doing the same. doug On 10/25/2012 03:34 PM, Ryan wrote: Doug, Yes, it's a longitudinal study since we MRI participants pre-training and post-training. On Thu, Oct 25, 2012 at 2:37 PM, Douglas N Greve <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>> wrote: I'm not sure I understand. Is this a longitudinal study? On 10/25/2012 01:26 PM, Ryan wrote: Doug, Also, how can I tell if it's thickening or thinning if red/blue corresponds to the group? Thanks for the help. ---------- Forwarded message ---------- From: *Douglas N Greve* <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>>> Date: Thu, Oct 25, 2012 at 12:20 PM Subject: Re: Files To: Ryan <wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu>> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu>>>> That contrast will compute training-controls. In the maps, red/yellow will mean training>controls, blue/cyan otherwise doug On 10/25/2012 12:47 AM, Ryan wrote: Doug, Here are the Xg.dat (where the first column is for controls and the second column is for training subjects) and mtx files, I didn't use the FSGD design. Please let me know if this is sufficient for you to answer my question, thank you very much. -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>> Phone Number: 617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>> <tel:617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>>> Fax: 617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>> <tel:617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>>> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail. -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> Phone Number: 617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>> Fax: 617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> Phone Number: 617-724-2358 <tel:617-724-2358> Fax: 617-726-7422 <tel:617-726-7422> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html>-- -Ryan
Doug, Just so our study is understandable, subjects completed a 6 week period of training or no training (i.e. the control condition) with a scan at the beginning and end of the period. Thus, I entered the pre and post-scans for training and control subjects in the input files. The names for all the subjects are kept in an ordered list, referenced by the other two files I describe below. In the Xg.dat file, the first column has a +1 for each control subject's pre-scan and a -1 for each control subject's post-scan. The second column has a +1 for each training subject's pre-scan and a -1 for each training subject's post-scan. The remaining columns each pertain to a specific subject's two scans, with 1's showing FreeSurfer which two scans are being compared pre to post. In the mtx file, the -1 references the first column in Xg.dat (control subjects) and the +1 references the second column in Xg.dat (training subjects). The remaining 0's refer to the other subjects or columns in Xg.dat. So in order to determine whether there's thickening or thinning in the controls and training subjects, would I still need to use an additional analysis with the contrasts [1 0 0 ....] and [0 1 0 ....]? Thank you.
On Tue, Oct 30, 2012 at 11:28 AM, Douglas N Greve <greve@nmr.mgh.harvard.edu
wrote:
Hi Ryan, I'm a little lost here. Can you resend your X and contrast matrices and explain what each column is? doug
On 10/26/2012 03:45 PM, Ryan wrote:
Doug, Actually my input is not the difference map, but the separate time points (it's timepoint 2 weighted with -1 and timepoint 1 weighted with 1, described in the matrix file I sent you). So in order to determine whether there's thickening or thinning in the controls and training subjects, would I still need to use the additional contrasts [1 0 0 ....] and [0 1 0 ....]? Thank you.
On Thu, Oct 25, 2012 at 3:48 PM, Douglas N Greve < greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.**edugreve@nmr.mgh.harvard.edu>> wrote:
And the input is already TimePoint2-TimePoint1? If so, then you will need two more contrasts: [1 0 0 ....] and [0 1 0 ....]. The first tells you if controls are thinning (blue) or thickening (red), the 2nd tells you if the training is doing the same. doug On 10/25/2012 03:34 PM, Ryan wrote: Doug, Yes, it's a longitudinal study since we MRI participants pre-training and post-training. On Thu, Oct 25, 2012 at 2:37 PM, Douglas N Greve <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.**edu<greve@nmr.mgh.harvard.edu><mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>>>>wrote:
I'm not sure I understand. Is this a longitudinal study? On 10/25/2012 01:26 PM, Ryan wrote: Doug, Also, how can I tell if it's thickening or thinning if red/blue corresponds to the group? Thanks for the help. ---------- Forwarded message ---------- From: *Douglas N Greve* <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>>> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>Date: Thu, Oct 25, 2012 at 12:20 PM Subject: Re: Files To: Ryan <wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu>> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu>>>> That contrast will compute training-controls. In the maps, red/yellow will mean training>controls, blue/cyan otherwise doug On 10/25/2012 12:47 AM, Ryan wrote: Doug, Here are the Xg.dat (where the first column is for controls and the second column is for training subjects) and mtx files, I didn't use the FSGD design. Please let me know if this is sufficient for you to answer my question, thank you very much. -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.**edu<greve@nmr.mgh.harvard.edu><mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>>> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>Phone Number: 617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>> <tel:617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>>> Fax: 617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>> <tel:617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>>> Bugs: surfer.nmr.mgh.harvard.edu/**fswiki/BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.**harvard.edu/fswiki/**BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting><http://surfer.nmr.mgh.**harvard.edu/fswiki/**BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting><http://surfer.nmr.mgh.**harvard.edu/fswiki/**BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting>FileDrop: www.nmr.mgh.harvard.edu/**facility/filedrop/index.html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.**edu/facility/filedrop/index.**html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html><http://www.nmr.mgh.harvard.**edu/facility/filedrop/index.**html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html><http://www.nmr.mgh.harvard.**edu/facility/filedrop/index.**html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html>The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/**complianceline<http://www.partners.org/complianceline>. If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail. -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.**edu<greve@nmr.mgh.harvard.edu><mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.**edu <greve@nmr.mgh.harvard.edu>>> Phone Number: 617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>> Fax: 617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>> Bugs: surfer.nmr.mgh.harvard.edu/**fswiki/BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.**harvard.edu/fswiki/**BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting><http://surfer.nmr.mgh.**harvard.edu/fswiki/**BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting>FileDrop: www.nmr.mgh.harvard.edu/**facility/filedrop/index.html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.**edu/facility/filedrop/index.**html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html><http://www.nmr.mgh.harvard.**edu/facility/filedrop/index.**html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html>-- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.**edu<greve@nmr.mgh.harvard.edu>Phone Number: 617-724-2358 <tel:617-724-2358> Fax: 617-726-7422 <tel:617-726-7422> Bugs: surfer.nmr.mgh.harvard.edu/**fswiki/BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.**harvard.edu/fswiki/**BugReporting<http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting>FileDrop: www.nmr.mgh.harvard.edu/**facility/filedrop/index.html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.**edu/facility/filedrop/index.**html<http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html>-- -Ryan
-- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu Phone Number: 617-724-2358 Fax: 617-726-7422
Bugs: surfer.nmr.mgh.harvard.edu/**fswiki/BugReportinghttp://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting FileDrop: www.nmr.mgh.harvard.edu/**facility/filedrop/index.htmlhttp://www.nmr.mgh.harvard.edu/facility/filedrop/index.html
Hi Ryan, I don't understand your model. This does not look like a standard repeated measures ANOVA. Is it supposed to be equivalent? doug
On 10/30/2012 02:07 PM, Ryan wrote:
Doug, Just so our study is understandable, subjects completed a 6 week period of training or no training (i.e. the control condition) with a scan at the beginning and end of the period. Thus, I entered the pre and post-scans for training and control subjects in the input files. The names for all the subjects are kept in an ordered list, referenced by the other two files I describe below. In the Xg.dat file, the first column has a +1 for each control subject's pre-scan and a -1 for each control subject's post-scan. The second column has a +1 for each training subject's pre-scan and a -1 for each training subject's post-scan. The remaining columns each pertain to a specific subject's two scans, with 1's showing FreeSurfer which two scans are being compared pre to post. In the mtx file, the -1 references the first column in Xg.dat (control subjects) and the +1 references the second column in Xg.dat (training subjects). The remaining 0's refer to the other subjects or columns in Xg.dat. So in order to determine whether there's thickening or thinning in the controls and training subjects, would I still need to use an additional analysis with the contrasts [1 0 0 ....] and [0 1 0 ....]? Thank you.
On Tue, Oct 30, 2012 at 11:28 AM, Douglas N Greve <greve@nmr.mgh.harvard.edu mailto:greve@nmr.mgh.harvard.edu> wrote:
Hi Ryan, I'm a little lost here. Can you resend your X and contrast matrices and explain what each column is? doug On 10/26/2012 03:45 PM, Ryan wrote: Doug, Actually my input is not the difference map, but the separate time points (it's timepoint 2 weighted with -1 and timepoint 1 weighted with 1, described in the matrix file I sent you). So in order to determine whether there's thickening or thinning in the controls and training subjects, would I still need to use the additional contrasts [1 0 0 ....] and [0 1 0 ....]? Thank you. On Thu, Oct 25, 2012 at 3:48 PM, Douglas N Greve <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>> wrote: And the input is already TimePoint2-TimePoint1? If so, then you will need two more contrasts: [1 0 0 ....] and [0 1 0 ....]. The first tells you if controls are thinning (blue) or thickening (red), the 2nd tells you if the training is doing the same. doug On 10/25/2012 03:34 PM, Ryan wrote: Doug, Yes, it's a longitudinal study since we MRI participants pre-training and post-training. On Thu, Oct 25, 2012 at 2:37 PM, Douglas N Greve <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>>> wrote: I'm not sure I understand. Is this a longitudinal study? On 10/25/2012 01:26 PM, Ryan wrote: Doug, Also, how can I tell if it's thickening or thinning if red/blue corresponds to the group? Thanks for the help. ---------- Forwarded message ---------- From: *Douglas N Greve* <greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>>>> Date: Thu, Oct 25, 2012 at 12:20 PM Subject: Re: Files To: Ryan <wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu>> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu>>> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu>> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu> <mailto:wmcgarry@gmu.edu <mailto:wmcgarry@gmu.edu>>>>> That contrast will compute training-controls. In the maps, red/yellow will mean training>controls, blue/cyan otherwise doug On 10/25/2012 12:47 AM, Ryan wrote: Doug, Here are the Xg.dat (where the first column is for controls and the second column is for training subjects) and mtx files, I didn't use the FSGD design. Please let me know if this is sufficient for you to answer my question, thank you very much. -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>>> Phone Number: 617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>> <tel:617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>>> <tel:617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>> <tel:617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>>>> Fax: 617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>> <tel:617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>>> <tel:617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>> <tel:617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>>>> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail. -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>>> Phone Number: 617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>> <tel:617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>>> Fax: 617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>> <tel:617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>>> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> <mailto:greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu>> Phone Number: 617-724-2358 <tel:617-724-2358> <tel:617-724-2358 <tel:617-724-2358>> Fax: 617-726-7422 <tel:617-726-7422> <tel:617-726-7422 <tel:617-726-7422>> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html> -- -Ryan -- Douglas N. Greve, Ph.D. MGH-NMR Center greve@nmr.mgh.harvard.edu <mailto:greve@nmr.mgh.harvard.edu> Phone Number: 617-724-2358 <tel:617-724-2358> Fax: 617-726-7422 <tel:617-726-7422> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting <http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting> FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html <http://www.nmr.mgh.harvard.edu/facility/filedrop/index.html>-- -Ryan
freesurfer@nmr.mgh.harvard.edu
-
Douglas N Greve -
Ryan