Using q dec we have run a single patient versus a group of healthy control subjects (n=20ish) and found significant differences even after FDR correction.
Could you describe the process qdec uses to compute these differences? Is it legitimate to report these single subject maps? Practically this is very useful for case reports but Im concerned about violating statistical rules.
Thanks!
We have dono something like this in Cortical thickness reduction of normal appearing cortex in patients with polymicrogyriahttps://surfer.nmr.mgh.harvard.edu/pub/articles/corticalPedroSep08.pdf
https://surfer.nmr.mgh.harvard.edu/pub/articles/corticalPedroSep08.pdf cheers,
PPJ --------------------------------------------------------------------- Pedro Paulo de Magalhães Oliveira Junior Diretor de Operações Netfilter & SpeedComm Telecom -- www.netfilter.com.br -- For mobile: http://www.netfilter.com.br/mobile
On Wed, Mar 23, 2011 at 14:21, Emily Rogalski erogalski@gmail.com wrote:
Using q dec we have run a single patient versus a group of healthy control subjects (n=20ish) and found significant differences even after FDR correction.
Could you describe the process qdec uses to compute these differences? Is it legitimate to report these single subject maps? Practically this is very useful for case reports but Im concerned about violating statistical rules.
Thanks!
Emily J Rogalski, PhD Assistant Research Professor Northwestern University Cognitive Neurology and Alzheimer's Disease Center (CNADC) 320 E Superior Street Searle Building 11th Floor Chicago, IL 60611 312-503-1155 phone 312-908-8789 fax erogalski@gmail.com
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I'm curious about the use of this method as well (thanks for the paper PPJ). Bruce/Doug, how exactly does QDEC treat this design? Can a single-subject comparison properly be done? Thanks.
-Derin
On Mar 23, 2011, at 4:11 PM, Pedro Paulo de Magalhães Oliveira Junior wrote:
We have dono something like this in Cortical thickness reduction of normal appearing cortex in patients with polymicrogyria
cheers,
PPJ
Pedro Paulo de Magalhães Oliveira Junior Diretor de Operações Netfilter & SpeedComm Telecom -- www.netfilter.com.br -- For mobile: http://www.netfilter.com.br/mobile
On Wed, Mar 23, 2011 at 14:21, Emily Rogalski erogalski@gmail.com wrote: Using q dec we have run a single patient versus a group of healthy control subjects (n=20ish) and found significant differences even after FDR correction.
Could you describe the process qdec uses to compute these differences? Is it legitimate to report these single subject maps? Practically this is very useful for case reports but Im concerned about violating statistical rules.
Thanks!
Emily J Rogalski, PhD Assistant Research Professor Northwestern University Cognitive Neurology and Alzheimer's Disease Center (CNADC) 320 E Superior Street Searle Building 11th Floor Chicago, IL 60611 312-503-1155 phone 312-908-8789 fax erogalski@gmail.com
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The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
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The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
Hi Emily, it is just performing a two "group" analysis, where one of your groups only has a single subject. There is nothing wrong with what you did, it all comes down to what conclusion you are trying to draw from it. I think it is ok for a case report. doug
Emily Rogalski wrote:
Using q dec we have run a single patient versus a group of healthy control subjects (n=20ish) and found significant differences even after FDR correction.
Could you describe the process qdec uses to compute these differences? Is it legitimate to report these single subject maps? Practically this is very useful for case reports but Im concerned about violating statistical rules.
Thanks!
Emily J Rogalski, PhD Assistant Research Professor Northwestern University Cognitive Neurology and Alzheimer's Disease Center (CNADC) 320 E Superior Street Searle Building 11th Floor Chicago, IL 60611 312-503-1155 phone 312-908-8789 fax erogalski@gmail.com mailto:erogalski@gmail.com
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freesurfer@nmr.mgh.harvard.edu
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Derin Cobia -
Douglas N Greve -
Emily Rogalski -
Pedro Paulo de Magalhães Oliveira Junior