Dear FreeSurfer experts,

we did a FreeSurfer-Analysis of cortical thickness in schizophrenia patients with motor abnormalities and found significant changes of cortical thickness in many brain regions. The Qdec p-maps showed many clusters (regions) with "surface" size exceeding 100mm2. We used a 15mm FWHM smoothing.

Does anabody have an idea if there is a reasonable neurobiological/ontological basis/explanation for this finding?

What is the exact size of M1 and SMA in mm2?

Thank you for your time!

Dusan

Hi Dusan

the one significant confound that you have to worry about is subject motion being substantially more in your patient population. You might try rating them for motion blinded to group and see if there is an inbalance.

cheers Bruce

On Sun, 17 Mar 2013, Dusan Hirjak wrote:

Dear FreeSurfer experts,

we did a FreeSurfer-Analysis of cortical thickness in schizophrenia patients with motor abnormalities and found significant changes of cortical thickness in many brain regions. The Qdec p-maps showed many regions with surface size exceeding 100mm2. We used a 15mm FWHM smoothing.   Does anabody have an idea if there is a reasonable neurobiological/ontological basis/explanation for this finding?   What is the exact size of M1 and SMA in mm2?     Thank you for your time!     Dusan

actually, I think you need to look up his email at UCSD as his MGH one bounced Bruce On Wed, 20 Mar 2013, Alice Burnett wrote:

Thanks very much, Doug and Bruce!

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From: Bruce Fischl [fischl@nmr.mgh.harvard.edu] Sent: 19 March 2013 00:00 To: Alice Burnett Cc: freesurfer@nmr.mgh.harvard.edu; rahul desikan Subject: Re: [Freesurfer] Medial orbitofrontal QA question

Hi Alice,

you might also see what Rahul (ccd) thinks if you send an image.

cheers Bruce On Mon, 18 Mar 2013, Alice Burnett wrote:

...

Hi FreeSurfer experts,

I have been working with a dataset we have run through FreeSurfer 5.0 and am interested in the medial orbitofrontal region (Desikan atlas). We have an unexpected surface area finding, so we want to rule out any systematic error in the generation of the area measurements. We followed the wiki instructions for processing and checked and edited all images as necessary, so the pial and white surface placement looks OK. I'm wondering, would you have any particular recommendations for QA checking the mOFC or things we should be looking out for?

Thanks so much! Alice

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