Hi Joseph

Not sure what youare trying to accomplish but if the beta coefficient for the timevariable is significant then that means that the slope of change overtime is significantly different from zero. Anyway, I think you canestimate subject-specific slopes using lme_mass_rfx which has as input theoutput of lme_mass_fit_Rgw or lme_mass_fit_vw plus their same inputs (take a look at the script's header).

Cheers -Jorge

De: "Lim Kai Wei, Joseph" joseph.lim@duke-nus.edu.sg Para: "freesurfer@nmr.mgh.harvard.edu" freesurfer@nmr.mgh.harvard.edu Enviado: Jueves 14 de abril de 2016 22:05 Asunto: [Freesurfer] Extract random effects (LME) for correlation

<!--#yiv5353829270 _filtered #yiv5353829270 {font-family:SimSun;panose-1:2 1 6 0 3 1 1 1 1 1;} _filtered #yiv5353829270 {font-family:"Cambria Math";panose-1:2 4 5 3 5 4 6 3 2 4;} _filtered #yiv5353829270 {font-family:Calibri;panose-1:2 15 5 2 2 2 4 3 2 4;} _filtered #yiv5353829270 {font-family:Tahoma;panose-1:2 11 6 4 3 5 4 4 2 4;} _filtered #yiv5353829270 {panose-1:2 1 6 0 3 1 1 1 1 1;}#yiv5353829270 #yiv5353829270 p.yiv5353829270MsoNormal, #yiv5353829270 li.yiv5353829270MsoNormal, #yiv5353829270 div.yiv5353829270MsoNormal {margin:0in;margin-bottom:.0001pt;font-size:12.0pt;font-family:"Times New Roman", serif;}#yiv5353829270 a:link, #yiv5353829270 span.yiv5353829270MsoHyperlink {color:#0563C1;text-decoration:underline;}#yiv5353829270 a:visited, #yiv5353829270 span.yiv5353829270MsoHyperlinkFollowed {color:#954F72;text-decoration:underline;}#yiv5353829270 span.yiv5353829270EmailStyle17 {font-family:"Calibri", sans-serif;color:#1F497D;}#yiv5353829270 .yiv5353829270MsoChpDefault {font-size:10.0pt;} _filtered #yiv5353829270 {margin:1.0in 1.0in 1.0in 1.0in;}#yiv5353829270 div.yiv5353829270WordSection1 {}-->Dear FS experts,    I used the spatiotemporal LME MATLAB toolbox to fit to my longitudinal data and performed some ad-hoc tests using the FDR2 correction.   I obtained some significant vertices on the fixed effect of slope (rate of change of cortical thickness – i.e. beta coefficient on time was significant).   I would like to proceed to show if individual variability in rate of change of cortical thickness – i.e. beta + random coefficient on time is correlated with any clinical and cognition measures.   May I know how can this be done? I do not seem to be able to do so from the output of lme_mass_fit_Rgw.   Thank you,  Joseph

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