I'm not sure what this is referring to, but you should be very careful flipping images. If you want to compare left and right, then use the xhemi tool https://surfer.nmr.mgh.harvard.edu/fswiki/Xhemi

On 9/4/18 10:41 AM, Martin Reuter wrote:

Hi Xiaoyu,

please keep the previous conversation as inline citation below so I know what we discussed before.

What I mean is to process every subject only once and not twice (with flipped images, if that is what you did?).

Then run xhemi analysis on the subject-level. Invert the sign of the left-right difference depending on which is the diseased hemi. Then do a regular analysis on that. Nothing paired.

Best, Martin

...

On 30. Aug 2018, at 18:29, Wang, Xiaoyu <xwang13@pennstatehealth.psu.edu mailto:xwang13@pennstatehealth.psu.edu> wrote:

Thanks Martin, Yes, I did mean to have the right hemisphere added to the left hemisphere as a new time point. Can you explain on what you mean by run every subject only once? Do you mean to run xhemi for all of the subjects and then run a paired analysis? Xiaoyu _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu mailto:Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer

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