Dear Christian,

They atlas is built using subfield segmentations on scans of older adult brains, but: 1. it’s also built with whole hippocampus segmentations of scans of subjects of a wider age range. 2. the deformation model should be able to account for large parts of the anatomical differences between subjects of different ages.

I would think this would be an issue for young kids that have markedly different brain volumes, but not for older kids and young adults that differ less dramatically from older adults.

I agree with this statement.

I hope this helps!

/Eugenio

-- Juan Eugenio Iglesias ERC Senior Research Fellow Translational Imaging Group University College London http://www.jeiglesias.com http://cmictig.cs.ucl.ac.uk/

From: freesurfer-bounces@nmr.mgh.harvard.edu on behalf of Christian Krog Tamnes c.k.tamnes@psykologi.uio.no Reply-To: Freesurfer support list freesurfer@nmr.mgh.harvard.edu Date: Wednesday, 10 January 2018 at 11:33 To: Freesurfer support list freesurfer@nmr.mgh.harvard.edu Subject: [Freesurfer] hippocampal subfields in younger populations

Dear FreeSurfer and hippocampal subfield segmentation developers,

I have noted that the FS6.0 hippocampal subfield segmentation procedure was developed using scans of older adult brains. Has the application of this method to kids, adolescents and/or young adults in any way been validated? Or do you have any thoughts regarding such use of the method?

I would think this would be an issue for young kids that have markedly different brain volumes, but not for older kids and young adults that differ less dramatically from older adults. But I would greatly appreciate any input regarding this.

Best regards,

Christian