Hi Prasad,

for me FreeSurfer worked pretty nicely with 7T data. Most critical parts are skull-stripping and surface alignment if intensities of the cortex vary a lot (e.g. darker cortex in temporal lobes). However, I haven’t tried the hippocampal subfields yet and have usually processed small cohorts of young healthy subjects only.

You have to deal with B1 inhomogeneities for obvious reasons, though. In that regard I got good results either using MP2RAGE (or MPRAGE with acquisition of a reference GRE), post processing correction by SPM and/or adjustments of the parameters of the N3 within FreeSurfer.

Best, Falk

Von: freesurfer-bounces@nmr.mgh.harvard.edu [mailto:freesurfer-bounces@nmr.mgh.harvard.edu] Im Auftrag von konasale prasad Gesendet: Dienstag, 7. Juni 2016 17:32 An: 'Alan Francis'; 'Freesurfer' Betreff: Re: [Freesurfer] Freesurfer program for 7 Tesla

No. not really. This paper should be useful. Thanks for sending this along.

From: Alan Francis [mailto:alandarkenergy@gmail.com] Sent: Tuesday, May 24, 2016 9:47 AM To: Freesurfer <freesurfer@nmr.mgh.harvard.edumailto:freesurfer@nmr.mgh.harvard.edu>; pnucleos@gmail.commailto:pnucleos@gmail.com Subject: Re: [Freesurfer] Freesurfer program for 7 Tesla

Hi Prasad: Hope all is well. Has someone replied to you on this question? I have enclosed an interesting article that compares 3T vs 7T that might be useful in guiding your analysis. best, Alan

On Mon, May 16, 2016 at 12:01 PM, konasale prasad <pnucleos@gmail.commailto:pnucleos@gmail.com> wrote:

Dear FSL experts,

We are trying to run freesurfer volume measurements, primarily subcortical regions along with cortical surface area and thickness. We are also interested in hippocampal subfields and shape analysis. I was wondering whether the program would be reliable compared to 3T (that we have done quite a few). Are there any known problems? If there are, please let me know the work arounds.

Thanks,

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Alan N. Francis PhD Instructor - Imaging Neuroscience Brain Imaging Center McLean Hospital Harvard Medical School 115 Mill Street, Belmont, MA 02478 alanf@bwh.harvard.edumailto:ezra_wegbreit@brown.edu afrancis@mclean.harvard.edumailto:afrancis@mclean.harvard.edu

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