Hi All,
I thought I'd share my recent experiences with the newest Freesurfer v.
5.10 and subcortical segmentation.
I ran a large sample of brains using the default stream of Freesurfer v.
5.10. The resulting hippocampal segmentations were extremely poor, yet on
the same sample of brains Freesurfer v. 4.xx did quite well.
Using tkregister, we discovered that the hippocampus is not being
registered well enough. Nick Schmansky one wrote in another post on this
list-serve that one difference between versions is that "talairach.xfm is
needed to compute nu.mgz, [and] talairach stage needs to precede the
nu_correct stage" He suggested using -use-mritotal in the recon-all command
to overcome tal-check failures.
I decided to try using -use-mritotal with this sample of my data, despite
tal-check not failing in the default stream. Resulting segmentations were
now both realistic and accurate, and near identical to those produced by
Freesurfer version 4.xx.
Have others experienced poor subcortical segmentation with current version
of Freesurfer? I should note, that I am having this problem on another
sample of MPRages of very good quality. I am concerned that future versions
of Freesurfer will limit use of the old stream to situations in which
tal-check fails.
Thanks you all.
Sincerely,
Joshua Lee