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Postdoc position: the noradrenergic system in Alzheimer’s disease using cognitive computational modeling and multimodal neuroimaging
by Jacobs, Heidi I.,PHD 06 May '26

06 May '26

Postdoctoral fellow position: Understanding how the noradrenergic system contributes to Alzheimer’s disease using cognitive computational modeling and multimodal neuroimaging at Massachusetts General Hospital / Harvard Medical School The Athinoula A. Martinos Center for Biomedical Imaging, located within the Department of Radiology at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) in Boston, Massachusetts, has an opening for a highly qualified postdoctoral individual to work with Dr. Heidi Jacobs. The Jacobs lab is focused on improving the early detection and early treatment of Alzheimer’s disease. The lab focuses on the neuromodulatory subcortical nuclei, in particular the locus coeruleus, using a variety of approaches, including 3T MRI, 7T MRI, PET imaging, pupil measurements, physiological recordings, blood-based markers, cognitive assessments and perturbational approaches, such as pharmacological manipulations and non-invasive vagus nerve stimulation. We are seeking a postdoctoral fellow to investigate the neural mechanisms underlying how the noradrenergic locus coeruleus system contributes to tau progression and cognitive decline. This position is intended for candidates with demonstrated experience in cognitive computational, and/or biophysical modeling of neural dynamics, and linking these models to in vivo human neuroimaging. The project will involve integrating multimodal imaging (e.g., sMRI, fMRI, MRS, PET) with pupillometry and advanced modeling approaches, including dynamic causal modeling (DCM) and reinforcement learning, in observational and pharmacological manipulation studies. In parallel, the lab develops approaches to characterize heterogeneity and temporal trajectories of disease progression using large-scale, well-characterized longitudinal datasets and advanced computational modeling. The lab also evaluates specific monoaminergic PET tracers to characterize age- and Alzheimer's disease-related changes in the noradrenergic and serotonergic systems from multiple perspectives. The successful candidate will also have the opportunity to contribute to these ongoing projects, depending on their expertise and interests. The Jacobs Lab consists of a multidisciplinary team of two instructors, three postdocs, two PhD-students, two clinical research coordinators and one project manager. This position is funded by NIH and foundation grants. The work in this project will be performed at the Athinoula A. Martinos Center for Biomedical Imaging, Charlestown Navy Yard. The candidate will be part of ongoing collaborations and work in a stimulating and inspiring environment. Our research group values open communication, motivation, optimism, mutual respect, teamwork, and innovative thinking. Dr. Jacobs is highly committed to individualized mentoring to help trainees achieve the most out of their postdoctoral candidature and to move forward in their career. At a minimum, the training environment will include professional development, one-on-one meetings, group lab meetings, frequent seminars and journal clubs, opportunities to present their work at national and international scientific conferences (i.e. Human Amyloid Imaging, Alzheimer’s Association International Conference), collaborations with partners within and outside MGH, and manuscript preparation for publication in high-impact journals. Dr. Jacobs has a strong funding record and will strongly encourage and provide mentorship in grant applications. Requirements: Candidates should hold a Ph.D. in Cognitive Neuroscience, Computational Modeling, Bio/medical Physics, Biomedical Engineering, Neuroimaging, or a related discipline. A strong publication record, including at least three first-author peer-reviewed publications with demonstrated research experience in neuroimaging combined with computational modeling approaches is required. Essential qualifications include: strong expertise in fMRI analyses and other neuroimaging methods (e.g. MRS, PET), advanced programming skills (e.g., Python, MATLAB), experience with computational modeling (e.g. cognitive computational modeling), a solid background in signal processing, and an ability to relate neuroimaging findings within a pathobiological framework of neurodegenerative diseases. The candidate should be highly motivated, a strong communicator (both verbally and in scientific writing), have an internal drive to learn independently, and be comfortable working as part of a larger collaborative team. A real necessity is a passion for science and a positive attitude. Experience in Alzheimer’s disease or aging research would be beneficial. Apply: The successful candidate will have joint appointments at MGH and HMS. If interested, please send your CV, letter describing interests, background, major achievements, skills, goals and contact information for three professional references. Please send application materials to Dr. Heidi Jacobs, Associate Professor of Radiology, at hjacobs(a)mgh.harvard.edu<mailto:hjacobs@mgh.harvard.edu> ___________________________________________ Heidi Jacobs, PhD Associate Professor of Radiology Massachusetts General Hospital | Harvard Medical School Department of Radiology Athinoula A. Martinos Center for Biomedical Imaging 149 13th Street Charlestown, MA 02129 hjacobs(a)mgh.harvard.edu www.heidijacobs.org<http://www.heidijacobs.org> Learn about what we do and why: https://shorturl.at/fEFa8 [A blue and black logo Description automatically generated] [signature_3581815700] Social media: Linkedin: https://www.linkedin.com/in/heidijacobs/ Bluesky: https://bsky.app/profile/heidijacobslab.bsky.social [Please note: I might send an email out of office hours, at weekends or during holidays. This suits me – but doesn’t mean I expect you to do the same]

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recon-all segmentation with motion artifacts
by Villagran Asiares, Alberto Gaston 05 May '26

05 May '26

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Finishing LeftHemi LGI and Not Starting RightHemi on Linux HPC
by Toms, Robert 04 May '26

04 May '26

External Email - Use Caution Dear FreeSurfer Team, I'm currently testing an LGI pipeline using FreeSurfer 8.0.0's -localGI recon-all command on our university's Linux-based computing cluster, aiming to get LGI statistics from 12,000ish subjects. We've got it successfully working for the most part, but we've run into the following issue: We currently run 50 subjects at a time in parallel (using TAC Launcher) across 4 nodes. In each batch of 50, 4 subjects (1 on each node) finish the left hemisphere of the -localGI command, and never start the right hemisphere process. They maintain the IsRunning.lh+rh file in their scripts directory, where it stays after the computation times out and is ended by the SLURM system. The other 46 complete both the lh and rh with no problems, apart from the occasional failure due to an MRI artifact. We've tried shrinking the batch sizes, looking for missing files, and checking matlab dependencies, and haven't been able to figure out the problem, though we've ruled out it being a memory issue. We've also separated these one-hemisphere-run folks out and tried running just the right hemisphere -localGI command on them. Few if any of these go through. I've checked the mailing list and haven't found anything relevant—any ideas? I've attached recon-all logs and IsRunning files from one of these groups of 4, as well as an additional recon-all log from an attempted right hemisphere rerun. Thank you for your time and attention, Robert Toms --------------------------------- Lab Manager, DAMMI Lab School of Brain & Behavioral Sciences University of Texas at Dallas ---------------------------------

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claustrum segmentation
by Vittorio Rispoli 03 May '26

03 May '26

External Email - Use Caution Dear FreeSurfer Developers, I am interested in a tool for automated claustrum segmentation for a dataset of 1x1x1mm in-vivo T1. Does the command "mri_claustrum_seg" provide an analysis with identical performance of what "mri_histo_atlas_segment_fireants" does in term of claustrum volumetric analysis and segmentation? Thanks in advance Best Vittorio

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Large discrepancy in left and right volumes of perirhinal cortices on FreeSurfer 7.1.1- Dissertation Help
by Schade, Rachel 28 Apr '26

28 Apr '26

External Email - Use Caution Dear FreeSurfer Developers, I was examining the perirhinal regions from BA_exvivo_thresh.stats when I noted a significant discrepancy between the left and right hemispheres, particularly obvious on the perirhinal volumes. On a set of 166 older adults, I found the following discrepancy: Left Mean (SD) Left Range Right Mean (SD) Right Range Volume 1694.01 (473.09) 872–3087 943.80 (244.34) 514–1638 Thickness 2.83 (0.27) 2.18 - 3.72 2.98 (0.31) 2.25 - 3.76 Surface Area 492.47 (83.31) 329 - 703 259.76 (38.55) 170 - 357 As you can see the mean and range are almost double that of the right for volume and surface area, though thickness seems relatively unaffected. I have included my colleague who looked at one participant with the most extreme asymmetry and found the following, where it looks like the entorhinal cortex is overlapping the perirhinal. Attached is a screen shot. I am using this for my dissertation due in a month and would love to know if this is a bug that could be resolved. Thank you for your time! Best. Rachel [UF] Rachel Schade Doctoral Candidate Public Health & Health Professions | Clinical & Health Psychology University of Florida rschade1(a)ufl.edu<mailto:rschade1@ufl.edu>

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Re: need license.txt urgently
by fsbuild 27 Apr '26

27 Apr '26

External Email - Use Caution Please try filling out and submitting the form at, https://secure-web.cisco.com/1T2tXCzg9gdR2IrrwN7O4uIv2RG-stuYEFyrM7wVo-on6U… The license file will be mailed to the email address you provide. - R. On 4/26/26 14:22, 马婧 (majing20000714(a)gmail.com) wrote:         External Email - Use Caution         I am so sorry to bother you.But I need FreeSurfer license.txt urgently for academic use.Thank you for your help. Name: MA JING Institution: JUNTENDO University  Email: majing20000714(a)gmail.com _______________________________________________ Freesurfer mailing list -- freesurfer(a)nmr.mgh.harvard.edu To unsubscribe send an email to freesurfer-leave(a)nmr.mgh.harvard.edu https://secure-web.cisco.com/1V5q9v0KJD9gU1usgVlg9iDjqzyifOArj_r7gCpnIJ3vxq… The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Mass General Brigham Compliance HelpLine at https://secure-web.cisco.com/1v4afNXIwJMdtkMisJBAXPZW0i6xnjRAMDRTibxQ-93nOu… <https://secure-web.cisco.com/1dWhB7785W_Lw1N9t1WR5J1NlBRCOpPLTHSjxx5pQO9IPApq-2EX3XFSwiND5tR4OycQ92gx9X_AENRTzLdj79jPwGB7beqLkqTVrfLvNlycVpvwo1SYdb99ZJv0HW9Bt5lr50qAH3mvt9YvJtoUWTXdwR5PGW3KWl2kZp3pL7-4xpIQvjWKnQDoYh9MOXMAjwpBymMVIxCuF0mcNSIL7_BmjSGHXgnH76DfTayaFbE2Bt2TQlLyXrphYhOjoYplYk1SG0TMdTW2qalvsvYVFSX58kwI1KhNk7ygGzPgrUxkjZmK7Wu4zBz4e__PPK9RiOUVVgEr2tK2UKQZprwaBBA/https%3A%2F%2Fwww.massgeneralbrigham.org%2Fcomplianceline%26gt; . Please note that this e-mail is not secure (encrypted). If you do not wish to continue communication over unencrypted e-mail, please notify the sender of this message immediately. Continuing to send or respond to e-mail after receiving this message means you understand and accept this risk and wish to continue to communicate over unencrypted e-mail.

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reply
by Lepus Li 27 Apr '26

27 Apr '26

External Email - Use Caution confirm b54752357af3c9c3243ab66e4ca4f9805f5d93ec

2 1

Confirm
by 許嘉琪 27 Apr '26

27 Apr '26

External Email - Use Caution confirm b54752357af3c9c3243ab66e4ca4f9805f5d93ec ᐧ

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need license.txt urgently
by 马婧 26 Apr '26

26 Apr '26

External Email - Use Caution I am so sorry to bother you.But I need FreeSurfer license.txt urgently for academic use.Thank you for your help. Name: MA JING Institution: JUNTENDO University Email: majing20000714(a)gmail.com

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confirm
by 許嘉琪 26 Apr '26

26 Apr '26

External Email - Use Caution confirm f7ac57421691dbb0f3dd3d33588d33bf4bc5878b ᐧ

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