Hi,
We are starting to use freesurfer to analyse some 400 brains. Many of the white matter surface reconstructions we are obtaining look quite noisy, with 'spikes' or 'protrusions' (I attach an image) and I wonder if these are normal results.... I would have thought that the white matter surface was smoother... does this surface look like what other people in the list are obtaining?
Second thing, concerning the folding index measures (Van Essen's folding index, FI):
FI = integral (Kmax * (Kmax-Kmin))
If the protrusions are artifacts, and as they are so sharp, wouldn't the FI be dominated by the high curvature of the protrusions? I thought that smoothing the surface before computing the FI may help take ride of these high frequencies. Is it possible to do this?
Finally, does someone in the list know of a paper(s) correlating the folding index to something else? (I asked this already some months ago)
Thanks in advance for your help!
best regards, roberto
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