[Freesurfer] Help with using family as random effect in sibling study

Hello!

I am trying to generate significance maps for a paired-difference analysis of cortical thickness using multiple pairs of siblings, and was wondering if there is a way to incorporate the family ID as a random effect/covariate in Freesurfer. Is it possible for the family ID for each sibling pair to be used as a categorical/discrete variable to then see the effect of family on cortical thickness in addition to the main effects we are looking at? Any guidance would be greatly appreciated!

Best, Casey

--

Casey Hopkinson

Clinical Research Coordinator Brain Genomics Laboratory Division of Psychiatric Neuroimaging Massachusetts General Hospital 149 13th Street, Charlestown, MA, 02129 (p) 617.643.3215