Hi Pietro
ICV (or eTIV) is computed using Randy Buckner's method, so you can cite his paper. Correcting for whole brain volume is certainly a reasonable thing to do but note that then you are testing a somewhat different hypothesis (that local atrophy is faster than whole-brain atrophy, as opposed to whether atrophy exists at all)
cheers Bruce
On Mon, 11 Jan 2016, pietro de rossi wrote:
Dear FreeSurfers, I am editing a paper on subcortical volumes in deficit schizophrenia after some reviewers' comments. On of them suggested me to correct the volumes of subcortical structures for whole brain volume instead of intracranial volume. In the reviewer's opinion ICV estimated by FreeSurfer 5.1 has a bad quality and is not reliable. However, neither the reviewer provides any evidence, nor I could find any... Is there any evidence for this?
Thanks in advance,
Pietro
-- Pietro De Rossi, MD
Sapienza Università di Roma, Facoltà di Medicina e Psicologia, Dipartimento NESMOS (Neuroscienze, Salute Mentale, Organi di Senso), Ospedale Sant'Andrea, Via di Grottarossa 1035-1039, 00189 Roma
NESMOS Department (Neurosciences, Mental Health and Sensory Functions), School of Medicine and Psychology, Sapienza University, Sant’Andrea Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy
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