[Freesurfer] T1w/T2w ratio maps: acquisition parameters T1w and T2w

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Dear FreeSurfer experts,

I would like to calculate myelin maps using the ratio between T1w and T2w scans. However, the acquisition parameters of the T2w images are slightly different (e.g.* voxel size T1w* = 1mm3* vs* *voxel size T2w* = 0.35 mm3 ;* T1w matrix:* 240 x 240 *vs* *T2w matrix:* 640 x 640). The first step of the protocol would involve a robust registration between the two MRI images (e.g. bbregister method) which would lead to a downsampling of the T2w images. My question is, could I conduct a reliable analysis of T1w/T2w ratio maps despite these differences in the acquisition parameters between both MRI sequences?.

Thank you very much in advance.

Best regards,

Steve.