Hi Vadim
the only problem will be that you've introduced an extra interpolation and the associated smoothing into your data. I suspect it will reduce the accuracy of the models for things like thickness estimation, but otherwise should be fine for e.g. functional overlaying.
cheers Bruce
On Mon, 29 Mar 2010, Vadim Axel wrote:
Dear experts,
I run my statistical analysis in SPM, while after coregistration I normalize my data (SPGR and EPI). Since my models and activations images are based on normalized data it's natural for me to use the normalized SPGR as an input for freesurfer inflation. Is it a good enough? Since I run inflation for each individual brain, I basically can do it for non-normalized anatomy, which is preferable, I think. However, then the coordinates are not MNI / Talariach. Attached the comparison of activations for normalized (left side) vs. non-normalized. It looks pretty similar, though the brains look of different shape. So, am I OK to do it on normalized brain?
Thanks for help, Vadim